Transient Lambert-Eaton myasthenic syndrome associated with systemic lupus erythematosus.
نویسندگان
چکیده
We present a patient who developed the Lambert-Eaton myasthenic syndrome (LEMS) in association with systemic lupus erythematosus (SLE). Severe proximal weakness with electrodiagnostic evidence of LEMS developed over 2 days during an exacerbation of cutaneous manifestations (bullous pemphigoid) associated with SLE. Following an increase in the daily dose of prednisone, there was complete clinical restitution of strength within 2 weeks and a slower resolution of electrodiagnostic abnormalities over 6 months. Marked serologic abnormalities were present at the onset and showed improvement over 6-8 months. LEMS had been infrequently described in association with SLE. The immunologic features of both SLE and LEMS suggest a linkage between the two diseases in this patient. We hypothesize that increased antibodies associated with exacerbation of SLE cross reacted with the neuromuscular junction membrane to produce LEMS.
منابع مشابه
Acquired Brown's syndrome in a patient with systemic lupus erythematosus.
A 27 year old woman with systemic lupus erythematosus (SLE) developed vertical diplopia with an apparent bilateral inferior oblique muscle palsy, resulting in a limitation of elevation of the globe in adduction. It resolved with systemic steroid treatment. A transient tenosynovitis affecting the superior oblique tendons was the probable underlying pathological mechanism. This is the first descr...
متن کامل[Frontiers in Bioscience E2, 122-126, January 1, 2010] 122 A review of autoimmune diseases associated with cancer
1. Abstract 2. Introduction 3. Autoimmune diseases associated with increased cancer risk 3.1. Rheumatoid arthritis (RA) 3.2. Systemic lupus erythematosus (SLE) 3.3. Sjögren’s syndrome (SS) 3.4. Celiac disease (Non-tropical sprue) 4. Autoimmune phenomenon with cancers paraneoplastic syndromes 4.1. Neurological 4.1.1. Neuromuscular junction disorders 4.1.1.1. Lambert-Eaton myasthenic syndrome (LE...
متن کاملStiff person syndrome as the initial manifestation of systemic lupus erythematosus.
Y. Chronic inflammatory demyelinating polyneuropathy followed by systemic lupus erythematosus and Sjögren syndrome: a case report. Two cases of chronic inflammatory demyelinating polyradiculo-neuropathy (CIDP) associated with Graves' disease. The association of myasthenia gravis and connective tissue diseases-the role of Sjögren's syndrome. features of patients with myasthenia gravis associated...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Muscle & nerve
دوره 12 1 شماره
صفحات -
تاریخ انتشار 1989